Some salient discussions:
- Functional remapping may be different in different brain regions (for eg. remapping in Sensory cortex in more evident vs. Hippocampus).
- Tonic GABA inhibition has benefits in acute phase of stroke (prevents excitotoxic damage?) but could be detrimental in chronic phase (prevents motor and learning recovery?).
- AMPA signalling has detrimental effects in acute phase of stroke (contributes to excitotoxic damage?) but could be beneficial in chronic phase (aids in motor and learning recovery?).
- So timing of therapy and emphasis on GABA-AMPA balance is crucial to stroke therapy.