Dr. Neethi Prem
Research Interests:
The functional complexity of our nervous system has always captivated me. The underlying mechanisms involved in various cognitive functions are the emergent property of interacting neural networks. Disturbances in these interacting neural networks as a result of genetic and neurodevelopmental predisposition are being hypothesized as the cause of many psychiatric disorders. And one such disorder is schizophrenia.
We have adopted an animal model of schizophrenia that is based on neurodevelopmental hypothesis. We are primarily interested in the understanding the neuronal mechanisms involved in cognitive dysfunction observed in this disorder. We intend to achieve this by using electrophysiological techniques such as local field potential and single unit activity from different regions of the brain known to be affected in this disorder during an ongoing cognitive task. The study will be supported with behavioral and immunohistochemical studies.
Ph.D. Thesis Title (2011-2018)
“Behavioral Validation of Cognitive Dysfunction in a Rat Model of Schizophrenia”
MPhil Title (2010)
"Efficacy of transplantation in host regeneration in ventral subicular lesioned rats : Assessment of neurogenesis in hippocampus."
Publications:
Rekha,J., Veena,L.R., Prem,N., Kalaivani,P., Choudhury,R., Alladi,P.A., Agrahari,M., Raju,T.R., and Kutty,B.M., NIH-3T3 fibroblast transplants enhance host regeneration and improve spatial learning in ventral subicular lesioned rats, Behav Brain Res., 218 (2011) 315-324.
Educational Background
Current Details
Department of Neurophysiology,
NIMHANS, Bangalore
[email protected]
The functional complexity of our nervous system has always captivated me. The underlying mechanisms involved in various cognitive functions are the emergent property of interacting neural networks. Disturbances in these interacting neural networks as a result of genetic and neurodevelopmental predisposition are being hypothesized as the cause of many psychiatric disorders. And one such disorder is schizophrenia.
We have adopted an animal model of schizophrenia that is based on neurodevelopmental hypothesis. We are primarily interested in the understanding the neuronal mechanisms involved in cognitive dysfunction observed in this disorder. We intend to achieve this by using electrophysiological techniques such as local field potential and single unit activity from different regions of the brain known to be affected in this disorder during an ongoing cognitive task. The study will be supported with behavioral and immunohistochemical studies.
Ph.D. Thesis Title (2011-2018)
“Behavioral Validation of Cognitive Dysfunction in a Rat Model of Schizophrenia”
MPhil Title (2010)
"Efficacy of transplantation in host regeneration in ventral subicular lesioned rats : Assessment of neurogenesis in hippocampus."
Publications:
Rekha,J., Veena,L.R., Prem,N., Kalaivani,P., Choudhury,R., Alladi,P.A., Agrahari,M., Raju,T.R., and Kutty,B.M., NIH-3T3 fibroblast transplants enhance host regeneration and improve spatial learning in ventral subicular lesioned rats, Behav Brain Res., 218 (2011) 315-324.
Educational Background
- M. Sc. In Biochemistry
- M.Phil. in Neurophysiology (Department of Neurophysiology, National Institute of Mental Health and Neurosciences)
Current Details
Department of Neurophysiology,
NIMHANS, Bangalore
[email protected]