Some important discussions:
- Why Calcium ions and not other cations (Na+,K+, Mg2+,etc.)? - It could be due to their stability in forming protein complexes and unique electron configuration.
- Why Ca2+ signalling in invitro and invivo studies show differences? - Possibly the compensatory endoplasmic reticulum uptake is more invivo.
- Ca2+ play a role in neural activity induced memory processes as well as neuroprotective mechanisms.